Pagano was disheartened that he didn't have NFL Network in his hospital room -- Irsay said he'd do his best to change that -- and wants to remain engaged with the team in some capacity. Patients with APL might develop serious blood-clotting or bleeding problems, according to the web site.
He'll spend 10 minutes with the janitor asking about how his ill mother is. He goes out of his way to treat people in a special way. He was hired by Grigson to replace Jim Caldwell. Previously Pagano served as defensive coordinator of the Baltimore Ravens. Pagano's brother, John Pagano, is in his first season as defensive coordinator of the San Diego Chargers. Pagano was diagnosed with Leukemia in , his first season as head coach of the Indianapolis Colts.
Why now? A two-minute drive, give up whatever. A statue of Bears founder George Halas stands outside their practice facility in Lake Forest, and former defensive coordinator Buddy Ryan is still one of the most celebrated Bears coaches ever, after leading the vaunted Bears to a dominating victory in Super Bowl XX.
The low number of red blood cells anemia can cause individuals with APL to have pale skin or fatigue. In addition, affected individuals may heal slowly from injuries or have frequent infections due to the loss of normal white blood cells that fight infection.
Furthermore, the leukemic cells can spread to the bones and joints, which may cause pain in those areas. Other general signs and symptoms may occur as well, such as fever, loss of appetite, and weight loss.
Treatment of APL requires cycles of multiple therapeutic agents, including chemotherapy, in three distinct phases: induction, consolidation, and maintenance. In the induction stage, patients typically receive a chemotherapeutic drug along with a medication called ATRA , in hopes of rapidly eradicating the promyelocytic white cells. While the medications are only given over a few days in the induction phase, patients such as Pagano are advised to stay in the hospital for weeks thereafter due to the risk of life-threatening infections that can arise while the white blood cell counts slowly recover.
After the patient has returned home from the hospital, the next stage of treatment is consolidation, in which patients receive several additional rounds of chemotherapy to build upon the effects of induction. Finally, during the maintenance phase patients receive multiple medications — some daily, some for weeks at a time on an occasional basis — typically for years after the end of the consolidation stage.
Cripe underscored the goal is remission, and a time frame definition is that the remission has lasted for three-to-five years. Cripe said Pagano knows he has received chemotherapy and he feels good.
Cripe did not estimate when Pagano could return to the Colts, given the physical nature of his job. He also would not cite statistics of remission, but said Pagano and his family think the rate sounds good. Cripe said there is no catching leukemia early or later, and treatment is the same, as is the outlook for recovery.
In general, bone marrow transplant is not used for this variety of the disease. Cripe looks forward to working with Pagano on his job return and the approach to his life, and he says the coach is "gung-ho" on fighting the disease. Cripe said indications are that Pagano is benefiting to the treatment at this time.
Cripe described the treatments as arduous and that for the next several weeks Pagano is at risk for complications day-by-day. The uncertainty is difficult, but Pagano is in good health otherwise. Pagano is in a protected environment, but is not in isolation.
Tina, has stayed with him. Cripe estimated there are approximately 1, APML cases across the country annually, with a typical median age range of to being most common for the onset. The median range for AML cases is about 70 years of age. It's probably not in the cards where he's going to be able to come back and be 'all-in' this season. The special thing about Chuck is he's a 'salt of the earth' man. You aspire to be the type of man he is.
He's going to be greatly missed in terms of his intensity, his energy, his leadership. Indianapolis is after three games, but Irsay says Pagano has had enough time to establish his program and that in his absence, there is one goal as the Colts host Green Bay this Sunday.
I know we will pull together. It's been a very difficult day, a lot to take in for our coaches, players and organization. Pagano joined the Colts on January 25 after four seasons with Baltimore, the final one as defensive coordinator. This is Pagano's 29th year in coaching, his 11th in the NFL. Offensive Coordinator Bruce Arians will take over the field direction of the Colts in Pagano's absence.
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